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KMID : 0356420000180010047
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Journal of Korean Andrology
2000 Volume.18 No. 1 p.47 ~ p.53
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Effects of Finasteride and Castration on Rat Ventral Prostate
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Oh Bong-Ryoul
Ahn Kyu-Youn
Kwon Dong-Deuk
Lim Jong-Hwan
Park Kwang-Sung
Ryu Soo-Bang
Park Yang-Il
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Abstract
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PURPOSE: To compare the mechanism of cell loss and changes in the ventral prostate of young adult Sprague-Dawley rats after treatment with finasteride, a potent 5 alpha-reductase inhibitor, or castration. MATERIALS AND
METHODS: Rats were divided into two group: finasteride treated and castrated. Finasteride-treated rats were given 1 mg/kg a day orally. The rats were sacrificed on days 1, 3, 5, 7, 10, 14, and 21. The ventral prostate was weighed and either prepared for histologic examination to detect apoptotic evidence or frozen in liquid nitrogen for the determination of the intraprostatic dihydrotestosterone (DHT) concentration and DNA content.
RESULTS: Both finasteride and castration decreased prostate weight and DNA content, the decrease being more pronounced in the castrated group. By 3 days of finasteride treatment, the intraprostatic DHT concentration decreased to a greater extent with no further significant change thereafter, whereas castration gradually decreased the intraprostatic DHT concentration up to day 10, with no further significant decrease thereafter. Apoptotic bodies were typically observed in castrated but not finasteride-treated animals.
CONCLUSIONS: Castration caused a more profound involution of rat ventral prostate than did finasteride. The extent of prostatic involution did not correlate with the intraprostatic DHT concentration. We could not find evidence of apoptosis in finasteride-treated animals.
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KEYWORD
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Castration, Dihydrotestosterone, Finasteride, Prostate, Rat,
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